Question

Is gastrin a local hormone?

Answer 1

Gastrin hormone:

1. Local hormones are signaling molecules that do not go into the bloodstream.
2. Gastrin is a peptide hormone that aids in gastric motility by stimulating the release of gastric acid (HCl) by the parietal cells of the stomach.
3. G cells are present in the stomach's pyloric antrum, the duodenum, and the pancreas.
4. Gastrin stimulates the release of histamines in enterochromaffin-like cells by binding to cholecystokinin B receptors, and it also triggers the insertion of K+/H+ ATPase pumps into the apical membrane of parietal cells (which increases H+ release into the stomach cavity).
5. Its release is triggered by peptides found in the stomach's lumen.