Question

Is haemophilia A or B worse?

Answer 1

Haemophilia A or B:

1. Haemophilia is a genetic disease.
2. It is caused by a mutation in the gene that codes for clotting factors.
3. This alteration or mutation may result in the clotting protein not functioning at all.
4. Haemophilia A and B are caused by clotting factor VIII and IX gene defects, respectively.
5. Clinically, haemophilia A is more severe than haemophilia B.
6. The type of mutation is known to be the most significant factor influencing the severity of haemophilia: null mutations are common in severe haemophilia A (about 80%), whereas missense mutations are common in severe haemophilia B (approximately 60%).