Question

What is microsatellite instability?

Answer 1

Microsatellite instability:

1. Microsatellite instability (MSI) is a type of genetic hypermutability caused by faulty DNA mismatch repair (MMR).
2. The existence of MSI is phenotypic proof that MMR is not functioning properly.
3. Due to a faulty DNA MMR system, the MSI phenotype is defined by the accumulation of many mutations across the genome, primarily in repeated sequences or microsatellites.