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Question

What is the net ATP gain from one glucose?


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Solution

ATP:

  1. Adenosine triphosphate (ATP) is the cellular energy source for usage and storage.
  2. ATP is also produced via the process of cellular respiration in a cell's mitochondria.
  3. This can be accomplished by aerobic respiration, which requires oxygen, or anaerobic respiration, which does not.

Net ATP gain from one glucose:

  1. In aerobic respiration, one glucose molecule results in a net ATP gain of 38 ATP.
  2. It comprises ATP generated during glycolysis, the link reaction, the TCA cycle, and oxidative phosphorylation in the electron transport system.

Glycolysis:

  1. It is the process of breaking down glucose to create energy.
  2. Glycolysis generates 2 ATP and 2 NADH, for a total of 8 ATP molecules.

Krebs cycle:

  1. It is a series of events in living organisms in which acetic acid or acetyl equivalent oxidation produces energy for storage in phosphate bonds (as in ATP)
  2. The Krebs cycle yields three NADH molecules (two cycles) and 18 ATP molecules.
  3. In two cycles, four FADH2 molecules are generated, yielding four ATP molecules.
  4. Two GTP molecules are created in two cycles, resulting in the release of two ATP molecules.

Electron transport chain:

  1. It is the metabolic mechanism through which electrons move from one carrier to another.
  2. In two cycles, oxidative phosphorylation produces two NADH molecules while releasing six ATP molecules.

Final Answer: All of the preceding events result in a net ATP gain of 38 molecules from a single glucose molecule.


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