Question

Where is the normal $\mathrm{PrP}$ protein found in the body?

Answer 1

Normal prion proteins:

1. The prion protein PrP is a surface protein in the outer area of many organs with high expression levels in the central and peripheral nervous systems.
2. Normal prion proteins are found on the surface of nerve cells.
3. When accidentally folded, it aggregates and damages brain tissue, causing neurodegenerative diseases.
4. The exact function of this protein is unknown, but researchers suggest a role in some critical processes of long fibrils that impair normal brain function.