The correct option is C Non-nutrient chemicals produced by the body in trace amount that act as intercellular messenger are known as hormones
Adenohypophysis is not under direct regulation of the hypothalamus. Neurohypophysis is under direct regulation of the hypothalamus.
Organs in the body like gastrointestine tract produce peptide hormones, heart produce atrial natriuretic factor (ANF) hormone, kidney produce erythropoietin and liver produce angiotensinogen.
Hormones are non-nutrient chemicals produced by the body in trace amount that act as intercellular messenger. They are secreted from endocrine glands. They act on their target organ and carry out specific functions.
Releasing and inhibitory hormone like Thyrotropin releasing hormone and dopamine, respectively, are produced by the hypothalamus.
So, statement C is correct in relation to the endocrine system.