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Question

Who isolated the first restriction endonuclease?


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Solution

Definition:

  1. A restriction enzyme or restriction endonuclease is an enzyme that cleaves DNA into fragments at or near specific recognition sites within the molecule known as restriction sites.
  2. Example: HIND III is the restriction endonuclease.

Discovery: Hamilton O. Smith discovered and isolated the first site-specific restriction endonuclease Hind III from the bacterium Haemophilus influenzae.


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