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Question

2-bromobutane is better SN2 substrate than isopropyl bromide.
Identify whether the above statement is correct and give the reason for your answer.

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Solution

2- Bromobutane is better SN2 substrate than isopropyl bromide. The above statement is incorrect.
Reactivity towards SN2 reaction depends upon the steric hindrance.
2-bromobutane offers more steric hindrance towards nucleophilic due to the presence of more alkyl group.
Isopropyl bromide has less steric hindrance towards nucleophile, therefore, it is a better substrate.

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