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Question

32. Fixed dose drug combinations (FDCs), are combinations of two or more active drugs in a single dosage form. Consider the following statements with reference to FDCs:
1. FDCs are considered to be effective for elderly patients or patients suffering from multiple disorders.
2. FDCs are less economic than single ingredient drugs.
3. Its therapeutic efficacy has not been proved scientifically.
Which of the above statement(s) is/are correct?

A
Only 2
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B
Only 2 and 3
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C
Only 1 and 3
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D
All of the above
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Solution

The correct option is C Only 1 and 3
FDCs are more economic than single ingredient drugs, hence second statement is wrong.

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Q.

A fixed-dose combination (FDC) is a formulation including two or more active pharmaceutical ingredients (APIs) combined in a single dosage form, which is manufactured and distributed in certain fixed doses. The advantages of Fixed-dose Drug Combination are:

1. Procurement, management and handling of drugs get simplified.

2. Eliminates drug shortages by simplifying drug storage and handling, and thus lowers risk of being "out of stock".

3. Drug interactions may lead to alteration of the therapeutic effect.

Select the correct code:

फिक्स्ड-डोज़ कॉम्बिनेशन (FDC) एक नियमन है, जिसमें दो या अधिक सक्रिय फ़ार्मास्युटिकल अवयव (APIs) शामिल हैं, जो एकल डोज़ रूप में संयुक्त होते हैं, जो कुछ निश्चित डोज़ में निर्मित और वितरित होते हैं। फिक्स्ड-डोज़ ड्रग कॉम्बिनेशन के लाभ हैं?

1. दवाओं की खरीद, प्रबंधन और हैंडलिंग सरल हो जाती है।

2. दवा की कमी को दूर करता है, तथा इस प्रकार "आउट ऑफ स्टॉक" होने के जोखिम को कम करता है।

3. दवाओं के अन्तरान्वन से चिकित्सीय प्रभाव में परिवर्तन हो सकता है।

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