$4 -$ Amino salicylic acid, called PAS, is an anti-tuberculosis drug. The proper method for its preparation involves a reaction of:

3 -

aminophenol with chloroform in an alkaline medium

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3 -

aminophenol with carbon dioxide in an alkaline medium under pressure

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c o n c . H N O_{3}

and

c o n c . H_{2} S O_{4}

on salicylic acid followed by catalytic reduction using

H_{2} / N i

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chlorine (limited amount) with

4 -

aminobenzoic acid in the pressure of

F e C l_{3}

, followed by boiling the product in aq. alkali

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Solution

The correct option is C $3 -$ aminophenol with carbon dioxide in an alkaline medium under pressure
The reaction is known as Kolbe's reaction.
Phenolic $- O H$ reacts with $N a O H / K O H$ to form phenoxide ion which is more reactive than parent phenol towards electrophilic aromatic substitution. Carbon dioxide is weak electrophile. Both $- O H$ and $- N H_{2}$ groups are ortho, para directing groups.

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The salicylic acid reacts with the neutral FeCl3 solution and with CH3OH in esterification reaction because it contains:

{M n O}_{4}^{-}

{M n O}_{3}^{-}

9.65

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[F e (C N)_{6}]^{4 -}

[F e (C N)_{6}]^{3 -}

[F e (C N)_{6}]^{3 -}

[F e (C N)_{6}]^{4 -}

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