Gene Therapy

Q.

Which Vector Is Used To Deliver Gene In Animal Cell?

Q.

Write short note on Genetic engineering. <!--td {border: 1px solid #cccccc;}br {mso-data-placement:same-cell;}--> [Textbook Question No.5e Pg no. 208]

Q.

What does gene therapy include?

Q.

The genetic defect - Adenosine Deaminase (ADA) deficiency may be cured permanently by

1. administering adenosine deaminase activators

2. introducing bone marrow cells producing ADA into cells at early embryonic stages

3. periodic infusion of genetically engineered lymphocytes having functional ADA C-DNA

4. enzyme replacement therapy

Q.

What is gene therapy?

1. A therapy in which all the faulty genes of the body are destroyed.

2. A technique to replace 'a faulty gene' by a normal healthy functional gene.

3. None of these.

4. Changing the genetic make up of sperms.

Q. The first clinical gene therapy was done for the treatment of

1. Cancer
2. Cystic fibrosis
3. AIDS
4. SCID

Q. First clinical gene therapy was given in 1992 to a 4 years old girl for

1. Adenine deficiency
2. Adenosine deficiency
3. Adenosine deaminase deficiency
4. Growth deficiency

Q.

Which kind of therapy was given in 1990 to a four year old girl with adenosine deaminase deficiency

1. Radiation therapy

2. Gene therapy

3. Chemotherapy

4. Immunotherapy

Q. Gene therapy helps in the treatment of ______.

1. Leukemia
2. Typhoid
3. PKT
4. Malaria

Q.

An example of gene therapy is

1. Production of injectable hepatitis B vaccine
   

2. Introduction of the gene for adenosine deaminase in persons suffering from Severe Combined Immuno Deficiency (SCID)
   

3. Production of vaccines in food crops like potatoes which can be eaten
   

4. Production of test tube babies by artificial insemination and implantation of fertilised eggs.

Q.

Which of the following are true for bone marrow?

1. HIV / AIDS

2. Typhoid fever

3. Malaria

4. Diabetes

Q. You have studied pharmacogenomics and work in a hospital where a highly potent yet experimental drug is being tested on cancer patients. After a few weeks, only a few patients seem to have their tumors shrunken in size. What would be your next course of action?

1. Try higher dosage of drug
2. Try a different drug altogether
3. Understand the genetic disposition of the patients who had positive result
4. Help create a new drug that works with varying genetic disposition

Q. Why is gene therapy needed?

1. Certain viral diseases need to be combated by gene silencing
2. Genetic disorders cannot be cured by drug based medicines
3. Gene therapy is a better cure for diseases as it has no side effects
4. Gene therapy can be designed to suit your genome and hence is more effective

Q. The genetic defect, adenosine deaminase (ADA) deficiency, may be cured permanently by

1. Periodic infusion of genetically engineered lymphocytes having functional ADA cDNA
2. Administering adenosine deaminase activators
3. Introducing bone marrow cells producing ADA into cells at early embryonic stages
4. Enzyme replacement therapy