Type I and II Diabetes

Q. Some of the steps involved in the production of human insulin are given below. Choose the correct sequence
i. Obtaining of gene for human insulin using c-DNA technology
ii. Culturing recombinant E-coli in bioreactors
iii. Purification of human insulin
iv. Insertion of human insulin gene into plasmid
v. Introduction of recombinant plasmid into E.coli
vi. Extraction of recombinant gene product from E-coli

1. i-iii-v-vi-ii-iv
2. i-iv-v-ii-vi-iii
3. iii-v-ii-i-vi-iv
4. ii-i-iv-iii-v-vi

Q.

State the role of insulin.

Q.

How is insulin synthesized in humans?

Q. is responsible for the production of insulin in human body.

1. Islets of Langerhans
2. Nephrons
3. Bowman's capsule

Q. Which among the following helps to orient the A and B protein chains of insulin?

1. D peptide
2. B peptide
3. A peptide
4. C peptide

Q. During synthesis of rat insulin through genetic engineering, the isolated DNA fragments corresponding to insulin gene were inserted in .

1. bacterial plasmid
2. bacterial genome
3. rat genome

Q. helps to orient the A and B protein chains of insulin.

1. A peptide
2. B peptide
3. C peptide

Q. Natural genetic engineer of plants is

1. Yeast
2. Agrobacterium tumefaciens
3. E. coli
4. Mycoplasma

Q. Genetically engineered insulin is considered better for human diabetic patients over that isolated from animals because __________________.

1. Insulin from other animals are not pure
2. Insulin expressed in bacterial cells are low molecular weight.
3. Genetically engineered insulin will not elicit immune response in human body.
4. Genetically engineered insulin is easily transported through blood stream.

Q. The genetically-modified (GM) brinjal in India has been developed for

1. Drought resistance
2. Insect resistance
3. Enhancing shelf life
4. Enhancing mineral content

Q. Choose the correct pair based on the information on insulin structure.

1. A chain
2. B chain
3. C chain
4. Pre-proinsulin
5. 35 amino acids
6. 30 amino acids
7. 110 amino acids
8. 21 amino acids

Q. ___(i)____ regulates blood sugar levels and is secreted from beta-cells of ___(ii)____.

1. (i)Insulin, (ii)liver
2. (i)Glucagon, (ii)liver
3. (i)Insulin, (ii)pancreas
4. (i)Glucagon, (ii)pancreas

Q. The genetically modified (GM) brinjal in India has been developed for ?

1. Enhancing mineral content
2. Drought resistance
3. Insect resistance
4. Enhancing shelf life

Q. Assertion
Beta cells regulate the blood sugar level.
Reason
Beta cells secrete insulin.

1. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion.
2. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion.
3. Assertion is correct but Reason is incorrect.
4. Both Assertion and Reason are incorrect.