Cyclosporin

Q. Certain antibiotics have multiple physiological effects like decreasing blood cholesterol levels and acting as an immunosuppressant.

1. True
2. False

Q. Assertion (A): A patient who has undergone organ transplantation, if not provided with cyclosporin A may reject the transplanted organ
Reason (R): Cyclosporin A inhibits activation of T cells and interferes with destruction of non-self cells

1. Both A and R are true and R is the correct explanation of A
2. Both A and R are true and R is not the correct explanation of A
3. A is true but R is false
4. Both A and R are false

Q. Match the column I with column II

Column I	Column II
A. Colchicine	I. Immuno-suppresant drug
B. Cyclosporin A	II. Induced abortion
C. GABA	III. Mitotic poison
D. Mifepristone	IV. Inhibitory neurotransmitter

1. A- III, B- I, C- IV, D- II
2. A- III, B- II, C- I, D- IV
3. A- IV, B- III, C- I, D- II
4. A- IV, B- I, C- II, D- III

Q.

Cyclosporin A used as immunosuppressive agent is obtained from

1. Bacterium Bacillus subtilis

2. Fungus Trichoderma polysporum

3. Fungus Tolypocladiuminflatum

4. both 1 and 2