Inheritance of Autosomal Recessive Disorders

Q.

Blue baby syndrome results from:

1. Excess of dissolved oxygen

2. Excess of TDS (Total Dissolved Solids)

3. Excess of chloride

4. Methaemoglobin

Q. Sickle-cell anaemia is caused due to the substitution of

1. Valine at the 6th position of alpha globin chain by glutamic acid
2. Glutamic acid at the 6th position of beta globin chain by valine
3. Valine at the 6th position of beta globin chain by glutamine
4. Glycine at the 6th position of alpha globin chain by glutamic acid

Q. Study the pedigree chart given below and identify the type of inheritance.

1. Autosomal recessive
2. Autosomal dominant
3. X-linked dominant
4. Incomplete dominance

Q. Given below is the pedigree of sickle cell anaemia in a family.


In this, the RBC of both parents will be

1. normal
2. sickle shaped
3. both normal and sickle shaped
4. cannot be determined

Q. Sickle-cell anaemia is

Q. Identify the statement(s) which are correctly matched:
I. Autosomal disorder: Affects females more than males
II. Mutation in a single gene: Mendelian disorder
III. Chromosomal disorder: change in one gene in a chromosome
IV. Pedigree charts: Knowledge of family history of a genetic disease helps in its construction