Antibody and Its Structure

Q. Identify D in the given diagram.

1. Antigen binding site
2. Light chain
3. Heavy chain
4. Paratopes

Q. Antibodies in our body are complex

1. lipoproteins
2. steroids
3. prostaglandins
4. glycoproteins

Q.

Hinge region in antibodies is important because

1. Provides flexibility to the antibody molecules

2. Helps change the shape of antibody

3. Helps in binding of antibody to pathogens

4. Prevents the antibody from degradation

Q.

Which of the following is not true about antibodies?

1. Antibodies have multiple antigen binding sites.

2. Antibodies are built from equal number of large (heavy) and small (light) chains.

3. The class of antibody molecule is determined solely by its heavy chain.

4. Antibodies are secreted and function away from the cell. They are not bound to the cell membrane.

Q.

How do B cells recognize antigens?

Q.

Describe the IgG Immunoglobulin.

Q. Identify D in the given diagram.

1. Antigen binding site
2. Light chain
3. Heavy chain
4. Paratopes

Q. Each functional immunoglobulin has two heavy chains and two light chains. If an immunoglobulin is unable to bind to antigen, what is it lacking?

1. Variable region of heavy chain
2. Variable region of light chain
3. Constant region of light chain
4. Variable region of both heavy and light chain

Q. Each functional immunoglobulin has two heavy chains and two light chains. If an immunoglobulin is unable to bind to antigen, what is it lacking?

1. Variable region of heavy chain
2. Variable region of light chain
3. Constant region of light chain
4. Variable region of both heavy and light chain

Q. Write the names of two antibiotic resistant genes found in plasmid $P^{BR322}$.

Q.

Antibodies are released into the bloodstream

1. True

2. False

Q.

Hinge region in antibodies is important because it

1. Provides flexibility to the antibody molecules

2. Helps change the shape of antibody

3. Helps in binding of antibody to pathogens

4. Prevents the antibody from degradation

Q.

Fill in the blanks.​
The proteins that are generated in our body and destroy the pathogens are termed as

Q.

Antibodies produced by B cells can attack both extracellular and intracellular pathogens

1. True

2. False

Q.
I. Antibodies are highly glycosylated proteins

II. Antibodies are made up of 2 identical heavy chains and 2 identical light chains

III. N-terminal end of light and heavy chain interacts with the antigen

IV. N-terminal end of the heavy chain interacts with the antigen

V. C-terminal end of light and heavy chain, interacts with the antigen

Choose the option which identifies the incorrect statements:

1. III, V
2. I, III
3. I, III, IV
4. IV, V

Q. The heavy and light chains of an antibody are linked together with the help of

1. phosphodiester bonds
2. hydrogen bonds
3. disulfide bonds
4. glycosidic bonds

Q.

Each immunoglobin has two heavy chains and two light chains, the antigen binding is present in:

1. Variable region of light chain

2. Variable region of both heavy and light chains

3. Variable region of heavy chain

4. Variable region of light chain

Q.

Antigen-binding site in an antibody, is found between:

1. Two heavy chains

2. One heavy and one light chain

3. Two light chains

4. Either between two light chains or between one heavy and one light chain

Q. Antigen determinant differs from antigen binding site in its

1. Location
2. Function
3. Structure
4. All the above

Q. Identify $A,D,E$ and $F$ in the diagram of an antibody molecule given below.

Q. What are antigenic determinants?

Q.

Choose the correct option for the numbers I to VI in the diagram given below:

1. I- Variable region, II - Antigen binding site , III- Light chain, IV-Constant region, V - heavy chain , VI - disulfide bonds

2. I - Variable region , II - Antigen binding site , III - Light chain , IV - Constant region, V- Heavy chain , VI-disulfide linkages

3. I- Antigen binding site, II - Variable region , III- Light chain, IV-Constant region, V - heavy chain , VI - disulfide bonds

4. I - Fc , II - Antigen binding site , III - Variable region , IV - Constant region, V- Heavy chain , VI-disulfide linkages

Q. Sketch and label structure of Antibody.

Q. Each immunoglobin has two heavy chains and two light chains .The antigen binding site is found in

1. Variable region of heavy chain
2. Variable region of light chain
3. Constant region of light chain
4. Variable region of both heavy and light chain

Q. If you suspect a deficiency of antibodies in a person, to which of the following would you look for confirmatory evidence?

1. Haemocytes
2. Serum albumins
3. Serum globulins
4. Fibrinogen in the plasma

Q.

State whether true or false:
Antibodies are released into the bloodstream.

1. True

2. False

Q. Antibodies in our body are complex

1. Lipoproteins
2. Steroids
3. Prostaglandins
4. Glycoproteins

Q.

Choose the correct option for the numbers I to VI in the diagram given below:

1. I - Antigen binding site, II - Variable region, III - Light chain, IV - Constant region, V - Heavy chain, VI - Disulfide bonds

2. I - Variable region, II - Antigen binding site, III - Light chain, IV - Constant region, V - Heavy chain, VI - Disulfide bonds

3. I - Variable region, II - Antigen binding site, III - Light chain, IV - Constant region, V - Heavy chain, VI - Disulfide linkages

4. I - Fc, II - Antigen binding site, III - Variable region, IV - Constant region, V - Heavy chain, VI - Disulfide linkages

Q. Which of the following are most abundant types of antibodies?

1. IgG
2. IgA
3. IgM
4. IgE

Q. Assertion :B-Lymphocytes produce an army of proteins against invading pathogen that are called antibodies Reason: The T-cells themselves do not secrete these antibodies but help B cell to produce them

1. Statement B is correct and A is incorrect
2. Both the statement are incorrect
3. Statement A is correct and incorrect
4. Both the statements are correct