Base Substitution

Q. Sickle cell anaemia is an example of

1. Single base substitution mutation
2. Insertion of a single base
3. Non-frameshift mutation
4. Deletion of a single base

Q.

Can mutated genes be corrected?

Q. How many polypeptide chains are present in single molecule of a globin protein?

1. 1
2. 3
3. 4
4. 2

Q. The given gel shows the lanes 1, 2 and 3. Lane 1 shows DNA ladder starting from 100 bp and so on. Lane 2 shows restriction enzyme digestion results of a plasmid containing normal human beta globin allele. Lane 3 shows restriction enzyme digestion of sickle cell anaemia of a plasmid containing diseased allele.

1. Both lanes 1 and 2 both contain 100-bp fragments
2. Only lane 2 contains a 175-bp fragment
3. Only lane 3 contains a 375-bp fragment
4. Both lanes 2 and 3 contain two equal-sized fragments
5. Only lane 3 contains a 300-bp fragment