Different Types of Antibodies

Q.

Antibodies present in colostrum which protect the new born from certain diseases is of

1. IgG type

2. IgA type

3. IgD type

4. IgE type

Q. Antigen binding site is present in

1. variable region of heavy chain of the antibody
2. variable region of light chain of antibody
3. Fab region of the antibody
4. Fc region of antibody

Q.

what is colostrum and what is its composition?

Q.

Which immunoglobulin is largest in size?

1. Ig A

2. Ig E

3. Ig D

4. Ig M

Q. Which immunoglobulin is the largest in size

1. IgA
2. IgD
3. IgM
4. IgE

Q.

Which of the following statements are true regarding IgM ?

1. All of these

2. IgM is a pentamer and is the largest immunoglobulin

3. IgM exists as monomer on the B cell surface and secreted form is a pentamer

4. IgM is involved in early primary immune response

Q. Antigen-binding site in an antibody is formed by the variable region of

1. two light chains
2. two heavy chains
3. one heavy chain and one light chain
4. only one light chain

Q. The type of immunoglobulin present in the colostrum secreted by mammary glands is:

1. IgM
2. IgA
3. IgG
4. IgE

Q.

Is colostrum important to the infant?

Q.

Match the antibody in Column I with the appropriate description in Column II:

$\begin{array}{cccc}& ColumnI& & ColumnII\\ 1.& lgA& a.& Maximumantigenbindingcapacity\\ 2.& lgD& b.& Predominantimmunoglobulininbodilysecretions\\ 3.& lgE& c.& Physiologicalroleunknown\\ 4.& lgG& d.& Mediatesallergicresponse\\ 5.& lgM& e.& Mediatesopsonisation,cancrossplacenta\end{array}$

1. 1-b, 2-c, 3-d, 4-e, 5-a

2. 1-e, 2-c, 3-d, 4-b, 5-a

3. 1-d, 2-c, 3-a, 4-b, 5-e

4. 1-c, 2-d, 3-a, 4-b, 5-e

Q.

What is the function of secretory protein in IgA?

1. Helps the IgA to bind to pathogens in saliva

2. Helps in the secretion of IgA as a dimer

3. Helps in the secretion of monomeric IgA

4. Helps in its secretion as a serum immunoglobulin

Q.

Match the antibody in Column I with the appropriate description in Column II

$\begin{array}{cccc}& ColumnI& & ColumnII\\ 1.& lgA& a.& Maximumantigenbindingcapacity\\ 2.& lgD& b.& Predominantimmunoglobulininbodilysecretions\\ 3.& lgE& c.& Physiologicalroleunknown\\ 4.& lgG& d.& Mediatesallergicresponse\\ 5.& lgM& e.& Mediatesopsonization,cancrossplacenta\end{array}$

1. 1-c, 2-d, 3-a, 4-b, 5-e

2. 1-d, 2-c, 3-a, 4-b, 5-e

3. 1-b, 2-c, 3-d, 4-e, 5-a

4. 1-e, 2-c, 3-d, 4-b, 5-a

Q.

Which of the following statements is/are true regarding IgM?

1. All of these

2. IgM is involved in early primary immune response

3. IgM is a pentamer and is the largest immunoglobulin

4. IgM exists as monomer on the B cell surface and secreted form is a pentamer

Q. Immunoglobulin found in mother's milk is

1. IgE
2. IgD
3. IgA
4. IgM

Q. An immunoglobin or the antibody has two heavy chains and two light chains. Where do we find the antigen binding site?

1. Variable region of heavy chain
2. Variable region of light chain
3. Constant region of light chain
4. Variable region of both heavy and light chain

Q. The image given below represents an antibody molecule. Identify the parts labelled as A, B and C.

1. A - Antigen binding site, B - Light polypeptide chain (L - Chain), C - Heavy polypeptide chain (H - Chain)
2. A - Light polypeptide chain (L - Chain), B - Antigen binding site, C - Heavy polypeptide chain (H - Chain)
3. A - Heavy polypeptide chain (H - Chain), B - Antigen binding site, C - Light polypeptide chain (L - Chain)
4. A - Antigen binding site, B - Heavy polypeptide chain (H -Chain), C - Light polypeptide chain (L - Chain)

Q.

Match the antibody in Column I with the appropriate description in Column II:

$\begin{array}{cccc}& ColumnI& & ColumnII\\ 1.& lgA& a.& Maximumantigenbindingcapacity\\ 2.& lgD& b.& Predominantimmunoglobulininbodilysecretions\\ 3.& lgE& c.& Physiologicalroleunknown\\ 4.& lgG& d.& Mediatesallergicresponse\\ 5.& lgM& e.& Mediatesopsonisation,cancrossplacenta\end{array}$

1. 1 - b, 2 - c, 3 - d, 4 - e, 5 - a

2. 1 - e, 2 - c, 3 - d, 4 - b, 5 - a

3. 1 - d, 2 - c, 3 - a, 4 - b, 5 - e

4. 1 - c, 2 - d, 3 - a, 4 - b, 5 - e

Q. Type of immunoglobulin present in colostrum / only in mother's milk is

1. IgA
2. IgG
3. IgE
4. IgD

Q. Drugs which cause malformations in embryo during pregnancy are called

1. Tranquilizer
2. Sedatives
3. Nicotine
4. None of the above
   
5. Teratogens

Q.

Which of the following statements is/are true regarding IgM?

1. IgM is a pentamer and is the largest immunoglobulin

2. IgM exists as monomer on the B cell surface, and its secreted form is a pentamer

3. IgM is involved in early primary immune response

4. All of these

Q. Antigen-binding site in an antibody is formed by the variable region of

1. two light chains
2. two heavy chains
3. one heavy chain and one light chain
4. only one light chain

Q. The secondary response in antibody-mediated immunity

1. Is characterized by a slow rise in antibody levels and then a gradual decline
2. Occurs when you first receive a vaccination against some disease
3. Is an intense response by memory cells to produce antibodies when an antigen is contacted again
4. Produces fewer but more responsive antibodies that occur during the primary response

Q. Immunoglobulin found in mother's milk is

1. IgE
2. IgM
3. IgD
4. IgA

Q.

What is the function of secretory protein in IgA

1. Helps in the secretion of IgA as a dimer

2. Helps in the secretion of monomeric IgA

3. Helps the IgA to bind to pathogens in saliva

4. Helps in its secretion as a serum immunoglobulin

Q. Which of the following best explains the difference between epitope and an antigen?

1. Antigens are recognised by B-cells and antibodies, epitope are recognised by T-cells.
2. An antigen is the part of an epitope where antibody or lymphocyte receptor binds.
3. An epitope is any foreign substance , an antigen is a foreign protein.
4. An epitope is part of an antigen where antibody or lymphocyte receptor binds.

Q. The antigen-binding site of the antibody molecules is called ''paratope''. Epitope recognizing part of the antibody comprises of

1. Variable part of heavy and light chains
2. Constant paret of heavy chains
3. Constant part of light and heavy & light chains
4. N & C terminal of both heavy & light chains

Q. Which of the following statements are true about Antibodies?
A. IgA protects body surfaces so called surface antibody
B. IgG found more or less in every body fluid and so called secretory antibody
C. IgD activates B-lymphocytes
D. IgM is having pentameric structure and having $5$ paratopes

1. A, B, C
2. Only C
3. A, B, C, D
4. A, B

Q. Antigen-antibody reactions are suppressed

1. In liver dysfunction
2. In chronic inflammatory reactions
3. By ACTH
4. By vitamin K

Q. Which of the following are types of antibodies, also known as isotypes?

1. IgH
2. IgM
3. IgE
4. IgC
5. IgG
6. IgD
7. IgF
8. IgA

Q. Incorrect match for immunoglobulin (Ig) type and it's location is:

1. IgG - intestine
2. IgD - B cell surface
3. IgA - secretions
4. IgE - intestine