Examples of Gene Therapy

Q. ADA is an enzyme which is deficient in a genetic disorder SCID. What is the full form of ADA?

1. Adenosine Deaminase
2. Adenosine Deoxy Aminase
3. Asparate Deaminase
4. Arginine Deaminase

Q. The first clinical gene therapy was done for the treatment of:

1. AIDS
2. Cancer
3. Cystic fibrosis
4. SCID

Q. Which kind of therapy was given in 1990 to a four-year old girl with adenosine deaminase(ADA) deficiency?

1. Immunotherapy
2. Radiation therapy
3. Gene therapy
4. Chemotherapy

Q.

What is Euphenics?

Q.

Assertion: The first clinical gene therapy for ADA was given to cure SCID.

Reason: The normal gene was delivered into the patient's cells using a retroviral vector.

1. Both assertion and reason are correct and reason is the correct explanation of assertion.
2. Both assertion and reason are correct but reason is not the correct explanation of assertion.
3. Assertion is correct but reason is incorrect
4. Both assertion and reason are incorrect

Q.

What is gene therapy example?

Q. Lesch Nyhan disease is an X-linked recessive disorder that causes neurological damage in human beings. A survey of 500 mates from a caucasion population revealed that 20 were effected with this disorder. What is the frequency of the normal allele in this population?

Q. Choose the correct statement for Widal test.

1. Clumping indicates the absence of antibody in serum
2. Clumping indicates the presence of typhoid specific antibodies in serum
3. No clumping indicates presence of typhoid
4. Clumping indicates absence of any typhoid antigen on the Widal card
   

Q. Which process is used to insert a normal gene into human cells to correct disorders?

1. Gene therapy
2. Live vector vaccines
3. Molecular cloning
4. Stem cell therapy

Q. Immune deficiency disorder, which occurs due to mutation in a gene, involved in the maturation of T and B lymphocytes is ________.

1. IDDM
2. Hashimoto disease
3. SCID
4. Pernicious anemia

Q. What is the permanent cure of adenosine deaminase (ADA) deficiency in children?

1. Bone marrow transplantation
2. Enzyme replacement therapy in which functional ADA is given to patient by injection
3. Infusion of genetically engineered lymphocytes (in which functional ADA-cDNA is introduced) into the patient's blood
4. Introduction of gene isolated from the bone marrow cells which produce ADA, into the cells of the patient at early embryonic stages

Q. The genes concerned with Asthma, Psoriasis and atopic dermatitis are present on many chromosomes.

1. False
2. True

Q. The first clinical gene therapy was done for the treatment of:

1. AIDS
2. Cancer
3. Cystic fibrosis
4. SCID

Q. Which kind of therapy was given in 1990 to a four-year-old girl with adenosine deaminase (ADA) deficiency?

1. Radiation therapy
2. Gene therapy
3. Chemotherapy
4. Immunotherapy

Q. Name at least three therapeutically important products obtained through recombinant genetic engineering.

Q. A coloured substrate was obtained consequent to an enzyme-substrate reaction.


More the cancer antigen present in the serum, more was the product obtained after the enzyme-substrate reaction. It was observed that the intensity of the colour only increased as the duration of the test was increased. This indicates one of the following below:

1. The patient was HIV positive
2. Presence of large amounts of cancer antibodies in the blood, the patient has cancer.
3. Person was infected with Gonorrhea
4. Patient was COVID positive

Q. The genes concerned with Asthma, Psoriasis, and atopic dermatitis are present on many chromosomes.

1. True
2. False

Q. SCID is caused by defective gene coding for the enzyme

1. Adenosine transaminase
2. Guanosine transaminase
3. Adenosine deaminase
4. Guanosine deaminase
5. Adenosine transferase

Q.

	Column-I Name		Column-II(Enzyme)		Column-II (Function)
(A)	Sickle cell anemi	(i)	Due to PP recessive gender	(P)	Valine is arranged in planed of glutamic
(B)	Phenyl ketonuria	(ii)	Homogenetisic acid, Oxidase enzyme is not produced	(Q)	In born error of metabolism
(C)	Alkaptonuria	(iii)	Disease following Mendelian principle	(R)	Urine turns black when comes in contact with air
(D)	Thalassemia	(iv)	Due to homozygous recessive genes	(S)	Haemoglobin is not formed in quantity in blood

Select proper piton from column-I, II and III:–

1. (A-ii-S)(B-iii-R)(C-i-Q)(D-iv-P)
2. (A-iv-P)(B-iii-R)(C-i-S)(D-ii-R)
   
3. (A-iv-P)(B-i-Q)(C-ii-R)(D-iii-S)
4. (A-iii-R)(B-i-S)(C-iv-P)(D-ii-S)

Q. The genes concerned with Asthma, Psoriasis, and atopic dermatitis are present on many chromosomes.

1. False
2. True

Q. Thalidomide is a non-barbiturate sedative drug which was to be given to pregnant women. Its use was withdrawn in 1961 because it resulted in phocomelia. This addition illustrates

1. Early abortion of foetus
2. Malformation of foetus
3. Erythroblastosis foetalis
4. Poor development of foetus

Q. Gene which does not allow the development of malignant tumours

1. Fitness gene
2. P - 10
3. Anticancer gene
4. Both B and C

Q. Identify the blank spaces marked A, B, C and D from the table given below.

Type of microbe	Scientific name	Product	Medical application product
(i) Fungus	A	Cyclosporin	B
(ii) C	Monascus purpureus	Statin	D

1. A–Trichoderma polysporum, B – Organ transplant patients, C – Yeast (fungus), D – Lowering of blood cholesterol.
2. A–Lowering of blood cholesterol, B – Trichoderma polysporum, C – Organ transplant patients, D – Yeast (fungus).
3. A – Organ transplant patients, B – Yeast (fungus), C – Lowering of blood cholesterol, D – Trichoderma polysporum.
4. A – Yeast (fungus), B – Lowering of blood cholesterol, C – Trichoderma polysporum, D – Organ transplant patients.

Q.

What is the first step in gene therapy to treat ADA deficiency?

1. Blood transfusions using genetically engineered lymphocytes.

2. Artificial culturing of the lymphocytes from the patient.

3. Production of genetically engineered lymphocytes.

4. Introduction of a cDNA coding for functional ADA gene into the lymphocytes.

Q.

What is the first step in gene therapy to treat ADA deficiency?

1. Blood transfusions using genetically engineered lymphocytes.

2. Artificial culturing of the lymphocytes from the patient.

3. Production of genetically engineered lymphocytes.

4. Introduction of a cDNA coding for functional ADA gene into the lymphocytes.

Q. Which kind of therapy was given in 1990 to a four-year-old girl with adenosine deaminase (ADA) deficiency?

1. Radiation therapy
2. Gene therapy
3. Chemotherapy
4. Immunotherapy

Q. Thalidomide is a non-barbiturate sedative drug, which was to be given to pregnant women. Its use was withdrawn in 1961, because it resulted in phocomelia. This condition illustrates

1. Early abortion of foetus
2. Poor development of foetus
3. Malformation of foetus
4. Erythroblastosis foetalis

Q. Maturation of B cell occurs only in bone marrow (in human), not in thymus right?

Q. ADA is an enzyme which is deficient in a genetic disorder SCID. What is the full form of ADA?

1. Adenosine Deoxy Aminase
2. Adenosine Deaminase
3. Asparate Deaminase
4. Arginine Deaminase

Q. How to prevent inflammation of tonsils?