Mechanism of Action of Drugs

Q. Study the diagram of synapse :


I. Which alphabet indicate the location of the receptor molecules ?
II. Which alphabet points to a synaptic vesicles ?
III. Which alphabet points to neurotransmitter?
IV. Which alphabet points to synaptic cleft ?

1. I-C II-A III-B IV-D
2. I-B II-A III-C IV-D
3. I-C II-A III-D IV-B
4. I-C II-D III-A IV-B

Q. What is a synapse? How the nerve impulses cross the chemical synapse?

Q. The synaptic vesicles in the neuron contain:

1. Dopamine
2. Cocaine
3. Both cocaine and dopamine
4. A drug addict will have more of cocaine in the vesicles

Q. How does cocaine alter the normal mechanism of neurotransmission?

1. Down’s syndrome
2. Sleeping sickness
3. Heamophilia B
4. Hepatitis – B

Q. How does cocaine alter the normal mechanism of neurotransmission?

1. Reuptake pump on the pre-synaptic membrane is blocked by cocaine
2. Reuptake pump on the post-synaptic membrane is blocked by cocaine
3. The synaptic vesicles release cocaine in the synaptic cleft which causes abnormal nerve stimulation
4. The synaptic vesicles release dopamine but it is unable to bind on the reuptake pump

Q. Identify I, II, III in the following image:

1. I - Vesicle with neurotransmitters, II - Synaptic cleft, III - Postsynaptic receptor
2. I - Vesicle with calcium ions, II - Extracellular fluid, III - Postsynaptic ion receptor
3. I - Vesicle with macromolecules, II - Synaptic space, III - Postsynaptic receptor
4. I - Vesicles, II - Extracellular fluid, III - Postsynaptic ion receptor

Q. The synaptic vesicles in the neuron contain

1. Dopamine
2. Both cocaine and dopamine
3. A drug addict will have more of cocaine in the vesicles
4. Cocaine

Q. How does cocaine alter the normal mechanism of neurotransmission?

1. Reuptake pump on the pre-synaptic membrane is blocked by cocaine
2. Reuptake pump on the post-synaptic membrane is blocked by cocaine
3. The synaptic vesicles release cocaine in the synaptic cleft which causes abnormal nerve stimulation
4. The synaptic vesicles release dopamine but it is unable to bind on the reuptake pump

Q. Identify I, II, III in the following image:

1. I - Vesicle with calcium ions, II- Extracellular fluid, III- Postsynaptic ion receptor area.
2. I - Vesicle with neurotransmitters, II - Synaptic cleft, III- Postsynaptic receptor area.
3. I - Vesicle with macromolecules, II- Synaptic space, III- Postsynaptic receptor area.
4. I - Vesicles, II- Extracellular fluid, III- Postsynaptic ion receptor area.