Rh Factor and It's Inheritance

Q.

Explain Rh-incompatibility in humans.

Q. Child death may occur in the marriage of

Q. If the father of a fetus is Rh positive and the mother is Rh negative, what are the chances that there will be a mother-fetus incompatibility problem? Assume that the couple already had a first child with no medical problems.

1. 0%
2. 100%
3. Less than 50%
4. At least 50%

Q. Erythroblastosis foetalis can result if

1. the Rh- mother is sensitized to the Rh+ antigen and the baby is Rh-
2. the Rh+ mother is sensitized to the Rh- antigen and the baby is Rh-
3. the Rh- mother is sensitized to the Rh+ antigen and the baby is Rh+
4. the Rh+ mother is sensitized to the Rh- antigen and the baby is Rh+

Q. A man with blood group 'A' marries a woman with blood group 'B'. What are all the possible blood groups of their offsprings?

1. A, B, AB and O
2. O only
3. A and B only
4. A, B and AB only

Q. Chances of erythroblastosis foetalis occurs during second pregnancy when the baby is

Q. Based on the pedigree chart describing the inheritance of an autosomal-dominant disease, what is the probability that person A will give birth to an affected child if she mates with a wild-type male.

1. 25%
2. 50%
3. 75%
4. 100%

Q. Rh antibody formed in Rh $-$ve mother during Rh incompatibility and develops Erythroblastosis fetalis is?

1. Surface Ag
2. Universal Ab
3. Secretory Ag
4. Allergic Ab

Q. How Rh anti D is given to pregnant women?

Q.

The value of $\cancel{\mathrm{IIII}}\mathrm{II}$ is -

1. $4$

2. $7$

3. $6$

4. $8$

Q. The problem due to Rh factor arises when the two blood (Rh${}^{+}$ and Rh${}^{-}$ ) mix up

1. Through transfusion
2. In a test tube
3. During pregnancy
4. All of the above

Q. The condition of erythroblastosis foetalis occurs only when

1. The husband is ${Rh}^{+}$ and wife is ${Rh}^{-}$
2. The husband is ${Rh}^{-}$ and wife is ${Rh}^{+}$
3. The mother is ${Rh}^{-}$ and the foetus is ${Rh}^{+}$
4. The mother is ${Rh}^{+}$ and the foetus is ${Rh}^{-}$

Q. The problem of erythroblastosis foetalis occurs when

1. Mother is Rh positive and father is Rh negative
2. Both father and mother are Rh positive
3. Both father and mother are Rh negative
4. Father is Rh positive and mother is Rh negative

Q. If a man Rh${}^{+}$ve marries a lady Rh${}^{-}$ve, then

1. No child will be born
2. First child will die
3. First child will survive
4. None of the above

Q. Erythroblastosis foetalis is also called as

1. Bleeder's disease
2. Haemolytic disease of new born
3. Malaria
4. Sickle cell anaemia

Q. If the foetus is Rh${}^{+}$ and mother is Rh${}^{-}$, then which of the following situation is likely to happen ?

1. Foetus might transmit antibody to mother's blood.
2. Foetus is attacked by the antibodies of mother's blood.
3. Foetus might transmit antigen to mother's blood.
4. Foetus is attacked by the antigen of mother's blood.

Q. (a) Human genetic diseases (b) Rh blood group incompatibility (C) Klinefelter's syndrome (d) Albinism (e) Haemophilia (f) Carcinoma

Q. The possibility of erythroblastosis foetalis occurring during the second pregnancy is when

1. the baby is Rh+ and mother is Rh-
2. the baby and mother are Rh+
3. the baby and mother are Rh-
4. the baby is Rh- and mother is Rh+

Q. In which of the following situations, there is a risk factor for children acquiring erythroblastosis foetalis?

1. Mother is Rh -ve and father is Rh -ve.
2. Mother is Rh -ve and father is Rh +ve.
3. Mother is Rh +ve and father is Rh +ve.
4. Mother is Rh +ve and father is Rh -ve.

Q. In which of the following situations, is there a risk factor for children of incurring erythroblastosis foetalis?

1. Mother is Rh -ve and father is Rh -ve.
2. Mother is Rh +ve and father is Rh +ve.
3. Mother is Rh -ve and father is Rh +ve.
4. Mother is Rh +ve and father is Rh -ve.

Q. Which one of the following couple were suggested by doctors to not have more than one child?

1. Rh${}^{+}$ male and Rh${}^{-}$ female
2. Rh${}^{-}$ male and Rh${}^{+}$ female
3. Rh${}^{+}$ male and Rh${}^{+}$ female
4. Rh${}^{-}$ male and Rh${}^{-}$ female

Q. HbA${}_2$ is composed of

1. ${\alpha }_2$ ${\gamma }_2$
2. ${\alpha }_2$ ${\delta }_2$
3. ${\alpha }_2$ ${\alpha }_2$
4. ${\alpha }_2$ ${\beta }_2$

Q. If two person with ${}^{\prime }A{B}^{\prime }$ blood group marry and have sufficiently large number of children, these children could be classified as ${}^{\prime }{A}^{\prime }$ blood group. ${}^{\prime }AB$ blood group ${}^{\prime }{B}^{\prime }$ blood group in $1:2:1$ ratio.
Modern technique of protein electrophoresis reveals presence of both ${}^{\prime }{A}^{\prime }$ and ${}^{\prime }{B}^{\prime }$ type proteins in ${}^{\prime }A{B}^{\prime }$ blood group individuals. This is an example of

1. Codominance.
2. Incomplete dominance.
3. Partial dominance.
4. Complete dominance.

Q. Assertion :Sickle-cell anemia is a genetically determined disorder affecting many new born babies. Reason: It is caused by heterozygosity for allele Hb${}^s$ producing a single amino acid substitution in the $\alpha$-chain of the normal haemoglobin molecule determined by allele Hb${}^A$.

1. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion.
2. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion.
3. Assertion is correct but Reason is incorrect.
4. Both Assertion and Reason are incorrect.

Q. Erythroblastosis foetalis is caused when fertilisation takes place between gametes of

1. $R{h}^{+}$ female and $R{h}^{-}$ male.
2. $R{h}^{-}$ female and $R{h}^{+}$ male.
3. $R{h}^{+}$ female and $R{h}^{+}$ male.
4. $R{h}^{-}$ female and $R{h}^{-}$ male.

Q. IgG antibodies against self-proteins

1. Occur only in patients with tumours
2. Are only produced in the spleen
3. Can cross the placenta
4. Are more common in men

Q. The possibility of erythroblastosis foetalis occurring during the second pregnancy is when

1. the baby and mother are Rh-
2. the baby is Rh+ and mother is Rh-
3. the baby and mother are Rh+
4. the baby is Rh- and mother is Rh+

Q. Biological marriage of one of the following should be avoided
or

After examining the blood groups of a couple, the doctor advised them not to have more than one child. The blood group of the couple are likely to be

or

In which of the following situations, is there a risk factor for children of incurring erythroblastosis foetalis

1. Rh+ male and Rh- female
2. Rh+ male and Rh+ female
3. Rh- male and Rh+ female
4. Rh- male and Rh- female

Q. Where do the antigen and antibody occur in the blood?