Enzymes as Drug Targets

Q. How to find the root of a biquadratic equation?

Q.

What type of forces are involved in binding of substrate to the active site of enzyme?

Q.

In the following questions a statement of Assertion (A) followed by a statement of Reason (R) is given. Choose the correct answer out of the following choices.
(a) Assertion and reason both are correct statements and reason explains the assertion.
(b) Both assertion and reason are wrong statements.
(c) Assertion is correct statement and reason is wrong statement.
(d) Assertion is wrong statement and reason is correct statement.
(e) Assertion and reason both are correct statements but reason does not explain assertion.
Assertion (A) In presence of enzyme, substrate molecule can be attacked by the reagent effectively.
Reason (R) Active sites of enzymes hold the substrate molecule in a suitable position.

Q.

Which site of an enzyme is called allosteric site?

Q.

Explain the term target molecules or drug targets used in medicinal chemistry.

Q.

Define the term chemotherapy ?

Q. Drugs used to bind to receptors, inhibiting its natural function and blocking a message are called:

Q.

Name the macromolecules that are chosen as drug targets.

Q. Drugs that block the binding site of an enzyme from a substrate are called ______

1. Enzyme inhibitors
2. Poisons
3. Messengers
4. Receptors

Q.

What happens when the bond formed between an enzyme and an inhibitor is a strong covalent bond?

Q. With respect to drug-enzyme interaction, identify the wrong statement.

JEE MAIN 2021

1. Allosteric inhibitor competes with the enzyme’s active site
2. Competitive inhibitor binds to the enzyme’s active site
3. Non-competitive inhibitor binds to the allosteric site
4. Allosteric inhibitor changes the enzyme’s active site

Q. Noradrenaline is one of the neurotransmitters that plays a role in mood changes.

1. True
2. False

Q.

Name the macro-molecules that are chosen as drug targets.

Q. $H_1-$ Receptor antagonists is a term associated with:

1. Antacids
2. Antiseptics
3. Antihistamins
4. Analgesics

Q. Drugs that bind to the receptor site and inhibit the natural function are called

1. antagonists
2. agonists
3. enzyme inhibitors

Q.

Drugs that bind to the receptor site and inhibit its natural function are called:

1. Antagonists

2. Inhibitors

3. Messenger

4. Receptor

Q.

Non-competitive inhibitor changes the active site of the enzyme after binding at___________.

Q. How do enzymes catalyse a chemical reaction in the living system? Explain drug target interaction taking the example of enzyme as target.

Q. Assertion :Competitive inhibitors compete with the natural substrate for their attachment on the active sites of enzymes. Reason: In competitive inhibition, inhibitor binds to allosteric site of the enzyme.

1. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
2. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
3. Assertion is correct but Reason is incorrect
4. Both Assertion and Reason are incorrect

Q.

Why are certain drugs called enzyme inhibitors?

Q.

Assertion and Reason
In the following questions a statement of assertion (A) followed by a statement reason (R) is given. Choose the correct answer out of the following choice..
(a) Assertion and reason both are correct statements but reason does not explain assertion.
(b) Assertion and reason both are correct and reason explains asssWon.
(c) Both assertion and reason are Wrong statements.
(d) Assertion is correct statement reason is wrong statement.
(e) Assertion is wrong statement reason is correct statement.

Assertion (A) Non-competitive inhibitor inhibits the catalytic activity of enzyme by binding with its active site.
Reason (R) Non-competitive inhibitor changes the shape of the active site in such a way that substrate can't recognise it.

Q.

Assertion and Reason
In the following questions a statement of assertion (A) followed by a statement reason (R) is given. Choose the correct answer out of the following choice..
(a) Assertion and reason both are correct statements but reason does not explain assertion.
(b) Assertion and reason both are correct and reason explains asssWon.
(c) Both assertion and reason are Wrong statements.
(d) Assertion is correct statement reason is wrong statement.
(e) Assertion is wrong statement reason is correct statement.

Assertion (A) Competitive inhibitors compete with natural substrate for their attachment on the active sites of enzymes.
Reason (R) In competitive inhibition, inhibitor binds to the allosteric site of the enzyme.

Q. Some drugs interact with enzymes and make them biologically inactive. Such drugs are called:

1. Enzyme promoters
2. Enzyme inhibitors
3. Coenzyme
4. All of these

Q. A certain compound occupied a site Y of an enzyme near to the active site. This immediately resulted in the change of shape of the active site. Y is called a/an ______

1. inactive site
2. binding site
3. competitive site
4. allosteric site

Q.

Explain the term target molecules or drug targets as used in medicinal chemistry.

Q.

Define the term chemotherapy.

Q. What type of forces are involed in binding of substrate to the active site of enzyme?

Q.

Assertion and Reason
In the following questions a statement of assertion (A) followed by a statement reason (R) is given. Choose the correct answer out of the following choice..
(a) Assertion and reason both are correct statements but reason does not explain assertion.
(b) Assertion and reason both are correct and reason explains asssWon.
(c) Both assertion and reason are Wrong statements.
(d) Assertion is correct statement reason is wrong statement.
(e) Assertion is wrong statement reason is correct statement.

Assertion (A) Enzymes have active sites that hold substrate molecule for a chemical reaction.
Reason (R) Drugs compete with natural substrate by attaching covalently to the active site of enzyme.

Q. How do enzymes help a substrate to be attacked by the reagent effectively?

Q. Drugs that bind to the receptor site and inhibit the natural function are called

1. antagonists
2. agonists
3. enzyme inhibitors