Synthesis Using Azide & Gabriel Synthesis

Q.

Why cannot aromatic primary amines be prepared by Gabriel phthalimide synthesis?

Q.

Which of the following amines cannot be prepared by Gabriel Synthesis?

1. Isopropyl amine

2. 2-phenylethyl amine

3. Butyl amine

4. N -methyl benzyl amine.

Q.

The total number of monohalogenated organic products in the following (including stereoisomers) reaction is:

A (Simplest optically active alkene)

Q. Why is Gabriel pthalamide synthesis preferred for synthesis of primary amines?

Q. Choose the correct statements among the following when treatment of $C{H}_{3}C{H}_{2}Br$ with $KN{O}_2$ and $AgN{O}_2$ is done.
I. The major product will be ethyl nitrite in case of $KN{O}_2$.
II. The major product will be nitroethane in case of $KN{O}_2$.
III. The major product will be ethyl nitrite in case $AgN{O}_2$.
IV. The major product will be nitroalkane in case $AgN{O}_2$.

1. I and II
2. II and III
3. I and IV
4. III and IV

Q. The functional group present in Cortisone are:

1. ether, alkene, alcohol
2. alcohol, ketone, ether
3. alcohol, ketone, amine
4. ether, amine, ketone

Q. The best method for preparing primary amines from alkyl halides without changing the number of carbon atoms in the chain is:

1. Hoffmann Bromamide reaction
2. Gabriel phthalimide synthesis
3. Sandmeyer reaction
4. Reaction with $N{H}_3$

Q.

What volume of 1 M NaOH (in ml) will be required to react completely with 100g of oleum which is 109% labelled?

Q. Glucose molecule reacts with X number of molecules of phenylhydrazine to yield osazone. The value of X is.

Q.

Which of the following method is used to prepare pure aliphatic primary amine

1. Gattermann - Koch reaction

2. GabrielPthalimide synthesis

3. Hoffmann degradation method

4. Carbylamine reaction

Q. The compound Ethyl isocyanide is prepared by the reaction between :

1. $C_2{H}_{5}Br$ and KCN
2. $C_2{H}_{5}Br$ and $N{H}_3$
3. $C_2{H}_{5}Br$ and AgCN
4. $C_2{H}_{5}Br$ and HCN

Q. What is the role of Ag2O, H2O in Hoffman exhaustive methylation?

Q.

Hydrolysis of XeF₆

Q. Which of the following reactions will give a secondary amine as the final nitrogen containing product?

1. 
2. 
3. 
4. 

Q. Which of the following carboxylic acids can be decarboxylated readily by heating to $100-{150}^{o}C$?

1. $C{H}_{3}COC{H}_{2}COOH$
2. $C{H}_{3}COOH$
3. $C{H}_2=CH-C{H}_2-COOH$
4. $C{H}_{3}C{H}_{2}COOH$

Q. Account for the following:
(a) Gabriel phthalimide synthesis is not preferred for preparing aromatic primary amines.
(b) On reaction with benzene sulphonyl chloride, primary amine yields product soluble in alkali whereas secondary amine yields product insoluble in alkali.

Q. Gabriel phthalimide reaction is used for the preparation of

1. Primary Aromatic Amines
2. Secondary Amines
3. Primary Aliphatic Amines
4. Tertiary Amines

Q.

Draw organic products formed in the following reaction.

Q. The reagent(s) with which the following reaction is accomplished is/are :

1. $H_{3}P{O}_2$
2. $C{H}_{3}C{H}_{2}OH$
3. $H_{2}O$
4. $H_{3}P{O}_3$

Q. Write a note a Gabriel phthalimide synthesis.

Q. The following dihaloalkanes gives an N-(haloalkyl)phthalimide on reaction with one equivalent of the potassium salt of phthalimide. Deduce the structure of the phthalimide derivative formed:

1. 
2. 
3. 
   both A and B in equal proportions
4. Only elimination occurs. Neither A nor B

Q. Gabriel phthalimide synthesis can be used for the synthesis of aromatic primary amines.

1. True
2. False

Q.

The following dihaloalkanes gives an N-(haloalkyl)phthalimide on reaction with one equivalent of the potassium salt of phthalimide. Deduce the structure of the phthalimide derivative formed:

1. Both A and B in equal proportions

2. 

3. Neither A nor B are formed. An elimination product is formed rather.

4. 

Q. Nitrobenzene is used for making aniline, an important chemical used in:

1. the crimping of wool
2. the making of glue
3. the dyeing industry
4. fast-drying varnish

Q. Amine that can't be prepared by Gabriel phthalimide synthesis is:

1. Aniline
2. Benzylamine
3. Methyl amine
4. Iso-butyl amine

Q. what is swarts reactio

Q. Treatment of compound O with $KMn{O}_4/H^{+}$ gave P, which on heating with ammonia gave Q. The compound Q on treatment with $B{r}_2/NaOH$ produced R. On strong heating, Q gave S, which on further treatment with ethyl 2-bromopropanoate in the presence of $KOH$ followed by acidification, gave a compound T.

The compound T is:

1. glycine
2. alanine
3. valine
4. serine

Q. what would be the correct sequence for the preparation of 3-Propynamine via Gabriel synthesis:

1. $K_{2}C{O}_3$ abstracts a proton to give a nucleophile
2. Phthalic acid reacts with ammonia to give phthalimide
3. Reaction of Nuleophile with 3-bromopropyne
4. Hydrolysis

1. 2; 1; 3; 4
2. 1; 3; 4; 2
3. 1; 2; 3; 4
4. 2; 1; 4; 3

Q. explain williamson ether synthesi ls in detail with limitations such as double bond character in case of aromatic reac†an t

Q. Which one of the following can be prepared by Gabriel phthalimide synthesis?

1. Aniline
2. 4-bromoaniline
3. $o$-toluidine
4. Benzylamine
5. N-methylethanamine