Inheritance of Autosomal Recessive Disorders

Q.

If both parents are carriers for thalassemia, which is an autosomal recessive disorder, what are the chances of pregnancy resulting in an affected child?

1. 100%

2. 25%

3. 50%

4. No chance

Q. Sickle cell anemia is :

1. Characterized by elongated sickle like RBCs with a nucleus
2. An autosomal linked dominant trait
3. Caused substitute of valine by glutamic acid in the beta globin chain of hemoglobin
4. Caused by a change in a single base pair of DNA

Q. Study the pedigree chart given below and identify the type of inheritance.

1. Autosomal recessive
2. Autosomal dominant
3. X-linked dominant
4. Incomplete dominance

Q. Study the pedigree chart given below:


What does it show ?

1. Inheritance of a sex-linked inborn error of metabolism like phenylketonuria
2. Inheritance of a condition like phenylketonuria as an autosomal recessive trait
3. The pedigree chart is wrong as this is not possible
4. Inheritance of a recessive sex-linked disease like haemophilia

Q. If both parents are carriers for thalassemia, which is an autosomal recessive disorder, what are the chances of pregnancy resulting in an affected child?

1. $Nochance$
2. $50\%$
3. $25\%$
4. $100\%$

Q. Study the pedigree chart given below :
What does it show ?

1. Inheritance of a recessive sex - linked disease like haemophilia
2. Inheritance of a sex-linked inborn errow of metabolism like phenylketonuria
3. Inheritance of a condition like phenylketonuria as an autosomal recessive trait
4. The pedigree chart is wrong as this is not possible

Q. Given below is the pedigree of sickle cell anaemia in a family.


RBC of both parents of the I generation

1. will be normal in shape
2. will be sickle shaped
3. will be both normal and sickle shaped
4. cannot be determined

Q. Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

1. Both are due to a qualitative defect in globin chain synthesis
2. Both are due to a quantitative defect in globin chain synthesis
3. Thalassemia is due to less synthesis of globin molecules
4. Sickle cell anemia is due to a quantitative problem of globin molecules

Q. Given below is the pedigree of sickle cell anaemia in a family.


In this, the RBC of both parents will be

1. normal
2. sickle shaped
3. both normal and sickle shaped
4. cannot be determined

Q.

Can hemophiliacs have babies?

Q. A man and a women who both appear normal have a child together who has sickle cell anaemia. Sickle cell anaemia is an autosomal recessive trait. The women becomes pregnant again and is told that she is carrying fraternal twins. What is the probability that both of the couple's twins will develop sickle cell anaemia?

1. $1/16$
2. $1/4$
3. $1/2$
4. $9/16$