A 30-year-old woman reports to the clinic for a routine physical examination. The examination reveals she is pregnant. Her plasma levels of TSH are high, but her total thyroid hormone concentration is normal. Which of the following best reflects the patient’s clinical state?

Graves’ diseases

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A hypothalamic tumour secreting thyrotropin- releasing hormone (TRH)

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Hashimoto’s disease

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A pituitary tumour secreting TSH

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Solution

The correct option is C Hashimoto’s disease
High plasma levels of TSH indicate inappropriately low levels
of free thyroid hormones in the circulation. This occurs during autoimmune destruction of the thyroid gland in persons with Hashimoto’s disease.

Elevated plasma levels of oestrogen in pregnancy increase hepatic production of TBG and hence the total amount (bound + free) of thyroid hormones in the circulation is elevated.
Plasma levels of thyroid hormones are also elevated in persons with Graves’ disease and in patients with a pituitary TSH-secreting tumour.

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Similar questions

Q. A woman presents to her physician complaining that her menstrual cycles are irregular. She reports that she menstruates each month, but she cannot predict when. After reporting the dates of her last 5 periods, her physician concluded that her cycle is normal, but that is a 35 days cycle. She reports that she wants to get pregnant, but cannot predict when ovulation will occur. Her physician will tell her that she should expect to ovulate on day.

Q. Assertion :In a regular medical examination of a small population, a 35 years old lady was found to have higher levels of oestrogen and progesterone in her blood. Reason: The lady is 12 weeks pregnant.

Q. A statement of assertion is followed by a statement of reason.

Assertion: In a regular medical examination of a small population, a 35 years old lady was found to have higher levels of oestrogens, progesterone in her blood.
Reason: The lady is 12 weeks pregnant.

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Q. Case:
The average duration of human pregnancy is about 9 months. Parturition in humans is induced by a complex neuroendocrine mechanism. Rekha has completed her 9 months of pregnancy and her expected delivery date has passed but she has not undergone labor. Both her and family got worried and went to the hospital to consult her obstetrician. A complete blood work was done and the doctor observed extremely low levels of certain hormones and high levels of hPL, estrogen, thyroxine, etc.
On further examination, the doctor revealed that her uterus is not showing vigorous contractions which are extremely needed for delivery of the foetus. The doctor took consent from Rekha and injected her with a medicine to promote uterine contractions. Also, her obstetrician counselled her about benefits of breast feeding and good practices for postnatal care of herself and the baby.

During parturition, the hormone released from maternal pituitary acts on uterus and causes strong uterine contractions which in turn stimulate further secretion of this hormone. This is a type of:
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Q. Case:
The average duration of human pregnancy is about 9 months. Parturition in humans is induced by a complex neuroendocrine mechanism. Rekha has completed her 9 months of pregnancy and her expected delivery date has passed but she has not undergone labor. Both her and family got worried and went to the hospital to consult her obstetrician. A complete blood work was done and the doctor observed extremely low levels of certain hormones and high levels of hPL, estrogen, thyroxine, etc.
On further examination, the doctor revealed that her uterus is not showing vigorous contractions which are extremely needed for delivery of the foetus. The doctor took consent from Rekha and injected her with a medicine to promote uterine contractions. Also, her obstetrician counselled her about benefits of breast feeding and good practices for postnatal care of herself and the baby.

Which of the following event is not important for initiation of parturition in a human female?
[0.7 mark]

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