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Question

A competitive inhibitor of succinate dehydrogenase is

A
Malate
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B
Oxaloacetate
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C
a -ketoglutarate
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D
Malonate.
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Solution

The correct option is D Malonate.
Competitive inhibition is a form of enzyme inhibition where binding of the inhibitor to the active site on the enzyme prevents binding of the substrate and vice versa. Malonate is a competitive inhibitor of the enzyme succinate dehydrogenase: malonate binds to the active site of the enzyme without reacting, and so competes with succinate, the usual substrate of the enzyme. So, the correct answer is option D.

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