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Question

A contraceptive pill has the capacity to prevent conception by

A
blocking fallopian tube
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B
inhibiting release of FSH & LH
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C
stimulating release of FSH & LH
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D
causing immediate degeneration of released ovum
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Solution

The correct option is B inhibiting release of FSH & LH
A contraceptive pill is used as a means to prevent unwanted pregnancy. There are a number of ways in which the contraceptive pill can function. The mechanism of action would differ based on whether the pill used is a steroidal or a non steroidal one. If a steroidal pill is used, it would have the chemical constituents as progestogen-estrogen combination or progestogen alone. Progestogen acts like progesterone. It inhibits the release of GnRH from the hypothalamus and as a result, the realease of LH and FSH from anterior pituitary is inhibited. In the absence of FSH, the ovarian follicles don’t develop. In the absence of LH, there is no ovulation. Since the ovarian follicles didn’t undergo development, there was no estrogen production. The estrogen component from the contraceptive pill compensates for the absence of estrogen production and helps in maintaining the normal thickening of the uterine wall.

Ovulation can be inhibited by the pills, but there is no degeneration of the ovum after it has been released from the follicle.

Use of the chemical contraceptives makes the uterine wall unsuitable for implantation. If non steroidal chemicals are used, e.g. centchroman, it targets the estrogen receptor on the uterus. The estrogen receptors are modified by the chemical in such a way that they are unable to bind estrogen. In the absence of estrogen, the uterus becomes unsuitable to support implantation.
Use of hormones causes the secretion of thick mucus which blocks the cervix, and acts as a plug, hence blocking entry of sperm into the uterus. There is no blockage at the fallopian tube.

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