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Question
(a) Draw a neat labelled diagram of a nucleosome.
(b) Mention what enables histones to acquire a positive charge.
(b) Mention what enables histones to acquire a positive charge.
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Solution
a) Labelled diagram of the nucleosome is given above.b) Histone is like a spool which needs to wind the DNA around. DNA is negatively charged and so, histone has to be positively charged for good interaction between DNA and histone. They have a highly positive charged N-terminus with many lysine and arginine residues (which are positively charged amino acids).
b) Histone is like a spool which needs to wind the DNA around. DNA is negatively charged and so, histone has to be positively charged for good interaction between DNA and histone. They have a highly positive charged N-terminus with many lysine and arginine residues (which are positively charged amino acids).
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