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Question

A frameshift mutation will have minimum effect when it leads to ______________

A
insertion of 2 bases
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B
deletion of 1 base
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C
deletion of 3 bases
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D
deletion of 2 bases
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Solution

The correct option is C deletion of 3 bases
A frame shift mutation is one where there is insertion or deletion of one or more bases in DNA sequences thereby, changing the way in which the sequence is read.

For example, here is a sequence of DNA and we are relating this sequence with the sentence “THE CAT AND DOG ARE BIG”.


If there is deletion of adenine in the 2nd codon, then the entire reading frame changes.

And as a result, the entire reading frame shifts to the left.

As given below, if there is deletion of 3 bases then the frame does not shift.

But even if one codon is lost or added it may lead to serious consequences.

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