A group of molecular biologists performed an experiment of transcription in which they used RNA polymerase without sigma (σ) factor. Which of the below statements will be more correct in this case?

Transcription will initiate from the initiation codon

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Transcription will not take place

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Sequence specific transcription will be taking place

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RNA Polymerase will not work

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Solution

The correct option is B Transcription will not take place
RNA polymerase will not be able to work for sequence selective transcription without the help of σ factor. Sigma factor (σ) plays an important role in identifying promoter regions. The sigma factor helps the RNA polymerase to bind properly to the site of the promoter and start transcription, resulting in mRNA molecule production.
Thus, when RNA polymerase lacks sigma (σ) factor transcription will not take place.

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