A kind of biotechnology involving manipulation of DNA is
In genetic engineering, rDNA technology is applied to several biotechnological processes for obtaining particular biochemical improvement of genetic makeup of an organism and fighting genetic defects. Denatuting is purely a mechanical process by which the hydrogen bonds that anneal Double-stranded DNA are broken. DNA replication is a biochemical process that purely clones an existing copy of DNA and hence doesn't manipulate or alter the DNA template.