The correct option is B Missence mutation
A point mutation in a sequence of DNA causing premature stop codon in the transcribed mRNA is known as nonsense mutation. The amino acid substitution that substitute one amino acid with a similar one, resulting in an less effective enzyme is called as leaky mutation. A mutation causing the complete disruption of the function of the protein is called as null mutation. A point mutation that changes a codon specifying a different amino acid is called as missence mutation. Option C is correct answer.