A potential difference of 10 V is needed to make a current of 0.02 A flow through a wire.
So potential difference, V = 10 V
Current, I = 0.02 A
Resistance of the wire, R = V/I
R = 10/0.02 = 500 Ω
The resistance will remain the same unless the wire is changed.
Now to make a current of 250 mA to flow through the wire, the potential difference required is:
V = IR
V = 250 x 10-3 x 500
V = 125 V
So a potential difference of 125 V is needed to make a current of 250 mA flow through the wire.