Question

A patient of diabetes mellitus excretes glucose in urine even when he is kept on a carbohydrate free diet because

• A. Fats are catabolised to form glucose
• B. Amino acids are catabolised in liver
• C. Amino acids are discharged in blood stream from liver
• D. Glycogen from muscles is released in blood stream

Answer 1

The correct option is A Fats are catabolised to form glucose

Diabetes mellitus occurs due to deficiency of insulin. Insulin is secreted from the β cells of islets of Langerhans of pancreas. Insulin acts on hepatocytes and adipocytes and increases the uptake of cellular glucose and its utilisation. This leads to movement of glucose to hepatocytes and adipocytes from the blood, thereby resulting in the decreased blood glucose levels. Therefore, decreased levels of insulin causes increased levels of glucose in blood. The increased levels of glucose are not only because of dietary carbohydrates but due to the breakdown of glycogen into glucose (gluconeogenesis) i.e. stored fats are catabolized to form glucose.

So, the correct answer is 'Fats are catabolised to form glucose'.