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Question

A person suffering from Addison's disease usually has

A
Gluco and mineralocorticoid deficiency
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B
Hypotension
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C
Dehydration
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D
Weight gain
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E
Decreased plasma glucose
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Solution

The correct option is E Decreased plasma glucose

Addison's disease is due to the deficiency of both glucocorticoids and mineralocorticoids. Due to the decrease in aldosterone secretion, the sodium and water levels fall quickly. This is due to increased excretion. This leads to diabetes insipidus as well as hypotension due to resulting low blood volumes.

A dip in cortisol levels leads to loss of appetite, weight loss, nausea, vomiting, muscle weakness and hypoglycemia (low blood glucose).

This disease can be treated and managed with both glucocorticoid and mineralocorticoid replacement therapy.


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