Question

A pleiotropic gene is ______.

• A. $I^A$
• B. $H{b}^S$
• C. $H{b}^A$
• D. $I^B$

Answer 1

The correct option is B $H{b}^S$

The gene having multiple phenotypic effects is called pleiotropic genes, e.g., sickle cell anaemia. Sickle cell anaemia is caused by the gene $H{b}^S$. When it is in a homozygous condition, sickle cell anaemia occurs or if it is in the heterozygous condition, act as a carrier. Sickle cell anemia causes a rapid breakdown of RBCs results in anaemia, increases heart attack and heart failure chances, also there is an accumulation of blood cells in the liver and spleen which affects the function of the organ.

So, the correct option is '$H{b}^S$’