A researcher found that cells from advanced stage of malignant tumour have abnormal chromosome number. Why would this happen?

Cancer cells are no longer density dependent.

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Cancer cells are no longer anchorage dependent.

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Chromosomally abnormal cells can still go through cell cycle checkpoints.

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Chromosomally abnormal cells can still have normal metabolism.

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Solution

The correct option is D Chromosomally abnormal cells can still go through cell cycle checkpoints.
Most of the malignant tumour cells replicate in a similar manner with normal mitosis, therefore, the abnormal chromosomes also get replicated with abnormal DNA strands creating a cancerous malignant tumour however malignant tumours do need anchorage for their growth howsoever these abnormal cells will inhibit normal metabolism.
so the correct option is 'Chromosomally abnormal cells can still go through cell cycle checkpoints.'

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