Let A (a, 0), B (0, b) be the points on the axes then ∠AOB = π/2 therefore circle OAB is on AB as diameter whose equation is
(x-a) (x-0) + (y-0) (y-b) = 0
Or x2+y2−ax−by=0
If (h, k) be the centre then h = a/2, k = b/2.
Since AB = c ∴a2+b2=c2
or 4h2+4k2=c2
∴ Locus of the centre is x2+y2=c2/4