Question

According to accepted concept of hormone action, if receptor molecules are removed from target organs, then the target organ will

• A. Continue to respond to hormone, but in opposite way
• B. Continue to respond to the hormone without any difference
• C. Continue to respond to hormone, but will require higher concentration
• D. Not respond to the hormone

Answer 1

The correct option is D Not respond to the hormone

According to accepted concept of hormone action, hormones such as protein and peptide hormones, are recognised and bound by receptors on the plasma membrane of target cells to form the hormone receptor complex.
Formation of this complex, results in the activation of secondary messengers, such as cyclicAMP, which in turn activate proteins that bring about the required physiological change.

Hence, formation of the hormone-receptor complex is essential to bring about physiological changes.
Therefore, if receptors are removed from cell surface of a target organ, the target organ stops responding to the hormone.