Question

Acid halides are more reactive than acid amides towards the hydrolysis.

• A. True
• B. False

Answer 1

The correct option is A True

The simple answer is that amide functional groups have some resonance stabilization from the nitrogen lone pair delocalizing through the N-C-O system, while acid chloride doesn't.

A better way to think about it, however, is thinking about the rate-limiting step- kicking off a leaving group from the tetrahedral intermediate. RNH- is never going to be a very good leaving group, but Cl- is a great leaving group.

So, acid halides are more reactive than acid amides.

Hence, the answer is 'A'.