Question

ADA - deficiency is caused due to the

• A. Deletion of gene
• B. Translocation
• C. Substitution
• D. Inversion

Answer 1

The correct option is A Deletion of gene

ADA is also called as Adenosine deaminase deficiency. It is an autosomal recessive disorder. It is caused due to the deletion of gene coding for promoter of enzyme adenosine deaminase. Enzyme adenosine deaminase is responsible for conversion of deoxyadenosine (toxic substance to lymphocytes) to deoxyinosine.

Thus, the correct answer is 'Deletion of gene.'