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Question

ADA deficiency results in

A
Decrease in yield of crop plants
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B
Chromosomal disorders
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C
Increased risk of infertility
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D
Inability of immune system to function normally
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Solution

The correct option is D Inability of immune system to function normally
Adenosine deaminase enzyme (ADA)
ADA (Adenosine deaminase) is the enzyme that is required for the proper functioning of the immune system. It breaks down deoxyadenosine into deoxyinosine which is not toxic to the immune cells.

ADA deficiency
ADA deficiency leads to accumulation of deoxyadenosine which is toxic to the immune cells (like lymphocytes).
ADA deficiency occurs due to substitution mutations in the ADA gene. More than 70 mutations have been identified in the ADA gene which are attributed to ADA deficiency.
Lack of ADA gene results in depletion of T-lymphocytes which further affects the activation of B cells. Thus, the immune system does not function normally in ADA deficiency patients.

Final answer
(B) Inability of the immune system to function normally


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