The correct option is C All of the above
The senescence process of the innate immune system is environmentally driven. Ageing affects physiological functions and can be defined as the accumulation of damage in molecules, cells and tissues over a lifetime, this often decreases an organism's capacity to maintain homeostasis in stress conditions and entails a greater risk for many diseases. Ageing is a multifactorial process that is determined by genetic and environmental factors. Thus, the correct answer is option D.