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Question

AGGTATCGCAT is a sequence from the coding strand of a gene. What will be the corresponding sequence of the transcribed mRNA?

A
ACCUAUGCGAU
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B
UGGTUTCGCAT
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C
AGGUAUCGCAU
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D
UCCAUAGCGUA
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Solution

The correct option is D UCCAUAGCGUA
The genetic information from one strand of the DNA is copied into RNA during transcription. Hence, synthesis of RNA occurs during transcription.

A transcription unit in DNA consists of three regions: promoter, structural gene and terminator. The promoter located towards 5'-end (upstream) and terminator located towards 3'-end (downstream) of the coding strand, flank the structural gene in a transcription unit.

In the transcription unit, the strand that has the polarity 3'→5' acts as a template, and is also referred to as a template strand.

The template strand of DNA serves in mRNA synthesis while the other strand that has the polarity 5'→3' is called a coding strand.

If the coding strand in a transcription unit has the sequence AGGTATCGCAT, then, it is known that the sequence of mRNA transcribed is the same as the coding strand of DNA. However, in RNA, thymine is replaced by uracil.

Hence, the sequence of mRNA will be AGGUAUCGCAU

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