The correct option is D Lethal gene effect
Lethal Gene - a gene that leads to the death of an individual; these can be either dominant or recessive in nature or alleles that cause an organism to die only when present in homozygous condition are called lethal alleles. The gene involved is considered an essential gene.
When Mendel's Laws were rediscovered, geneticists believed that mutations would only alter the appearance of a living organism. However, it was discovered that a mutant allele could cause death. When an essential gene is mutated, it can result in a lethal phenotype. If the mutation is caused by a dominant lethal genotype, the heterozygote for the allele will show the lethal phenotype, the homozygote dominant is impossible. If the mutation is caused by a recessive lethal genotype, the homozygote for the allele will have the lethal phenotype.