Question

All of the following are prosthetic groups in conversion of pyruvate to acetyl CoA reaction, except

• A. Mn
• B. Thiamine pyrophosphate and coenzyme A
• C. Lipoic acid
• D. NAD

Answer 1

The correct option is A Mn

Pyruvate decarboxylation is a reaction that uses pyruvate to form acetyl-CoA, releasing NADH, a reducing equivalent, and carbon dioxide via decarboxylation. This reaction is very common in most organisms as a link between glycolysis and the citric acid cycle. In organisms that perform aerobic respiration, the reaction is usually catalyzed by the pyruvate dehydrogenase complex. The prosthetic groups involved in this reaction are TPP, co-enzyme A, lipoic acid and NAD. Mn does not act as a prosthetic group to the above reaction.

Thus, the correct answer is option A.