Question

All of the following are prosthetic groups in pyruvate to acetyl co-A reaction, except

• A. Mn
• B. Thiamine pyrophosphate and Coenzyme A
• C. Lipoic acid
• D. NAD

Answer 1

The correct option is A Mn

Pyruvate Dehydrogenase Complex converts pyruvate to acetyl co-A.

The complex is composed of three enzymes

1. Pyruvate decarboxylase (E1)

2. Dihydrolipoamide transacetylase (E2)

3. Dihydrolipoamide dehydrogenase (E3)

and five coenzymes

1. Thiamine Pyrophosphate (TPP)

2. Lipoic Acid – lipoamide

3. FAD

4. $NA{D}^{+}$

5. CoA