Question

Choose the correct option-

Alzheimer's disease in humans is associated with the deficiency of?

• A. dopamine
• B. gamma-aminobutyric acid
• C. acetylcholine
• D. glutamic acid

Answer 1

The correct option is C

acetylcholine

The correct option is C.

Explanation of correct option

1. Acetylcholine is a neurotransmitter of the parasympathetic nervous system that carries out functions like slowing heart rate, dilating blood vessels, increasing body secretions, contracting smooth muscles, etc.
2. A reduced concentration and function of acetylcholine results in Alzheimer's disease.
3. Various cognitive, behavioral, and psychological issues are seen in this disorder.

Explanation of incorrect option

Option A:

1. Dopamine is a neurotransmitter that helps in the conduction of impulses between neurons.
2. The deficiency of dopamine is linked to Parkinson's disease.

Option B:

1. Gamma-aminobutyric acid (GABA) is a neurotransmitter known to produce a calming effect by blocking signals in the central nervous system.
2. The deficiency of GABA is linked to various disorders related to anxiety, depression, schizophrenia, Huntington's disease, muscle spasticity, dystonia, etc.

Option D:

1. Glutamic acid is an alpha-amino acid used in the synthesis of proteins.
2. It also acts as an excitatory neurotransmitter.
3. The deficiency of glutamic acid in the brain results in mental exhaustion, concentration issues, and insomnia.

Final answer: Alzheimer's disease in humans is associated with the deficiency of acetylcholine.