Question

Alzheimer's disease in humans is associated with the deficiency of

• A. glutamic acid
• B. acetylcholine
• C. gamma aminobutyric acid (GABA)
• D. dopamine

Answer 1

The correct option is B acetylcholine

Alzheimer's disease is characterized by a markedly reduced concentration of acetylcholine in hippocampus and neocortex, caused by degeneration of cholinergic neurons. Acetylcholine is essential in learning and memory. However, despite the correlation between the cholinergic defect and intellectual impairment in Alzheimer's disease, the effect of substitution therapy with cholinergic is very limited. Especially in younger Alzheimer patients, the degenerative process also affects other transmitter systems. Particularly the concentrations of serotonin, somatostatin, and glutamate are significantly reduced. It is not elucidated how these transmitter defects contribute to symptomatology. The serotonin defect is thought to underlie the emotional and behavioral symptoms. The somatostatin defect is correlated to the reduced cerebral metabolism and thus might be a central phenomenon. The glutamate defect has been suggested to represent the neurochemical correlate to clinical dementia because the activity in the hippocampal glutamatergic synapses is normally increased during learning. Therapeutically, the multiple transmitter defects imply that simple transmitter substitution can be expected to be of only limited value in Alzheimer's disease.

So the correct option is B, acetylcholine