Among the compounds, the most susceptible to nucleophilic attack to carbonyl group is

CH₃COCl

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CH₃COOCH₃

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CH₃CONH₂

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CH₃COOCOCH₃

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Solution

The correct option is A
CH₃COCl

Acid chlorides are more reactive towards nucleophilic attack due to more positive charge on carbonyl carbon.

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Among the given compounds, the most susceptible to nucleophilic attack at the carbonyl group is

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The most characteristic reaction of aldehyde and ketones is nucleophilic addition to carbon oxygen double bond. Aldehyde and ketones are easily susceptible to nucleophilic addition because of structural features. The trigonal planar arrangement of groups around the carbonyl carbon atom means that the carbonyl carbon atom is relatively open to attack from above and below the plane of carbonyl group. The partial positive charge on the carbonyl atom means that it is especially susceptible to attack by a nucleophile

Aldehyde reacts with $2^{\circ}$ amines to form

Q. When a nucleophile attacks a carbonyl compound, the one which is most reactive towards the nucleophile is:

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Among the compounds, the most susceptible to nucleophilic attack to carbonyl group is

The correct option is A CH3COCl Acid chlorides are more reactive towards nucleophilic attack due to more positive charge on carbonyl carbon.

The correct option is A
CH₃COCl

Acid chlorides are more reactive towards nucleophilic attack due to more positive charge on carbonyl carbon.