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Question

Among the given compounds, the most susceptible to nucleophilic attack at the carbonyl group is:

A
CH3COCl
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B
CH3CHO
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C
CH3COOCH3
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D
CH3COOCOCH3
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Solution

The correct option is A CH3COCl
The most susceptible to nucleophilic attack at the carbonyl group is acetyl chloride (CH3COCl). In general, acid chlorides are most susceptible to nucleophilic attack at the carbonyl group as chloride ion is a very good leaving group.

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